Depletion of KIN17, a human DNA replication protein, increases the radiosensitivity of RKO cells.

@article{Despras2003DepletionOK,
  title={Depletion of KIN17, a human DNA replication protein, increases the radiosensitivity of RKO cells.},
  author={Emmanuelle Despras and Laurent Miccoli and Christophe A Cr{\'e}minon and Dany Rouillard and Jaime F. Angulo and Denis Biard},
  journal={Radiation research},
  year={2003},
  volume={159 6},
  pages={748-58}
}
The human KIN17 protein is a chromatin-associated protein involved in DNA replication. Certain tumor cell lines overproduce KIN17 protein. Among 16 cell lines, the highest KIN17 protein level was observed in H1299 non-small cell lung cancer cells, whereas the lowest was detected in MeWo melanoma cells. Cells displaying higher KIN17 protein levels exhibited elevated RPA70 protein contents. High KIN17 protein levels may be a consequence of the tumorigenic phenotype or a prerequisite for tumor… CONTINUE READING