Depletion of Immunoglobulin M Memory B Cells is Associated with Splenic Hypofunction in Inflammatory Bowel Disease

@article{Sabatino2005DepletionOI,
  title={Depletion of Immunoglobulin M Memory B Cells is Associated with Splenic Hypofunction in Inflammatory Bowel Disease},
  author={Antonio di Sabatino and Maria Manuela Rosado and Rachele Ciccocioppo and Paolo Cazzola and Raffaele Morera and Gino R Corazza and Rita Carsetti},
  journal={The American Journal of Gastroenterology},
  year={2005},
  volume={100},
  pages={1788-1795}
}
OBJECTIVES:IgM memory B cells that are responsible for the protection against infections by encapsulated bacteria, require the spleen for their generation and/or survival. Since the association between inflammatory bowel disease and functional hyposplenism is well described, our aim was to verify whether IgM memory B cells mirror the reduced splenic function in Crohn's disease and ulcerative colitis patients.METHODS:Peripheral blood samples were obtained from 32 Crohn's disease and 29… CONTINUE READING

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