Depletion of FGF acts as a lateral inhibitory factor in lung branching morphogenesis in vitro

@article{Miura2002DepletionOF,
  title={Depletion of FGF acts as a lateral inhibitory factor in lung branching morphogenesis in vitro},
  author={Takashi Miura and Kohei Shiota},
  journal={Mechanisms of Development},
  year={2002},
  volume={116},
  pages={29-38}
}
Previous studies have shown that the interaction of positive and inhibitory signals plays a crucial role during lung branching morphogenesis. We found that in mesenchyme-free conditions, the lung epithelium exerted a lateral inhibitory effect on the neighbouring epithelium via depletion of fibroblast growth factor 1 (FGF1). Contrary to previous suggestions, bone morphogenetic protein 4 could not substitute for the inhibitory effect. Based on of this observation, we used a reaction-diffusion… CONTINUE READING

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