Depletion of Cd4+ T Cells Causes Reactivation of Murine Persistent Tuberculosis despite Continued Expression of Interferon γ and Nitric Oxide Synthase 2

@article{Scanga2000DepletionOC,
  title={Depletion of Cd4+ T Cells Causes Reactivation of Murine Persistent Tuberculosis despite Continued Expression of Interferon γ and Nitric Oxide Synthase 2},
  author={Charles A Scanga and V P Mohan and Keming Yu and Heather Joseph and K. O. Tanaka and John Chan and JoAnne L. Flynn},
  journal={The Journal of Experimental Medicine},
  year={2000},
  volume={192},
  pages={347 - 358}
}
Tuberculosis is a major cause of death in much of the world. Current estimates are that one-third of the world's population is infected with Mycobacterium tuberculosis. Most infected persons control the infection but in many cases may not eliminate the organism. Reactivation of this clinically latent infection is responsible for a large proportion of active tuberculosis cases. A major risk factor for reactivation of latent tuberculosis is HIV infection, suggesting a role for the CD4(+) T cell… CONTINUE READING

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