Depletion of CTCF in Breast Cancer Cells Selectively Induces Cancer Cell Death via p53

Abstract

CCCTC-binding factor (CTCF), a ubiquitous 11-zinc finger multifunctional protein, has distinct molecular functions, such as transcriptional activation, repression, and chromatin barrier activity, in a locus-specific manner. Elevated CTCF levels in breast cancer cells are known to contribute to tumorigenesis; however, the underlying mechanism remains elusive… (More)
DOI: 10.7150/jca.18818

5 Figures and Tables

Topics

  • Presentations referencing similar topics