Depletion of CD4+CD25+ regulatory T cells enhances interleukin-2-induced antitumor immunity in a mouse model of colon adenocarcinoma.

Abstract

Interleukin 2 (IL)-2 induces antitumor immunity and clinical responses in melanoma and renal cell carcinoma. However, IL-2 also increases the number of CD4(+)CD25(+) regulatory T (Treg) cells that suppress antitumor immune responses. The aim of the present study was to elucidate the effect of depletion of Treg cells on IL-2-induced antitumor immunity. IL-2… (More)

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@article{Imai2007DepletionOC, title={Depletion of CD4+CD25+ regulatory T cells enhances interleukin-2-induced antitumor immunity in a mouse model of colon adenocarcinoma.}, author={Hisashi Imai and Masanao Saio and Kenichi Nonaka and Tatsuhiko Suwa and Naoki Umemura and Guan-Feng Ouyang and J. Nakagawa and Hiroyuki Tomita and Shinji Osada and Yasuyuki Sugiyama and Yosuke Adachi and Tsuyoshi Takami}, journal={Cancer science}, year={2007}, volume={98 3}, pages={416-23} }