Depletion of CD25+ regulatory cells uncovers immune responses to shared murine tumor rejection antigens.

Abstract

Although it is known that the immune system can mount responses to a variety of tumors it is clear that most tumors exhibit weak or even undetectable immunogenicity. Recent findings suggest that the lack of tumor immunogenicity is partly due to a population of cells called CD4+ CD25+ regulatory T cells since depletion of these cells in mice can result in… (More)

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