Depletion of BBS Protein LZTFL1 Affects Growth and Causes Retinal Degeneration in Mice.

@article{Jiang2016DepletionOB,
  title={Depletion of BBS Protein LZTFL1 Affects Growth and Causes Retinal Degeneration in Mice.},
  author={Jiangsong Jiang and Kanyarat Promchan and Hong Jiang and Parirokh Awasthi and Heather Marshall and Adam S. Harned and Ven Natarajan},
  journal={Journal of genetics and genomics = Yi chuan xue bao},
  year={2016},
  volume={43 6},
  pages={
          381-91
        }
}
Bardet-Biedl syndrome (BBS) is a heterogeneous disease characterized by deficiencies in various organs that are caused by defects in genes involved in the genesis, structural maintenance, and protein trafficking of cilia. Leucine zipper transcription factor-like 1 (LZTFL1) has been identified as a BBS protein (BBS17), because patients with mutations in this gene exhibit the common BBS phenotypes. In this study, we generated a knockout mouse model to investigate the effects of LZTFL1 depletion… CONTINUE READING
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