Depletion of 43-kD growth-associated protein in primary sensory neurons leads to diminished formation and spreading of growth cones

@article{Aigner1993DepletionO4,
  title={Depletion of 43-kD growth-associated protein in primary sensory neurons leads to diminished formation and spreading of growth cones},
  author={Ludwig Aigner and Pico Caroni},
  journal={The Journal of Cell Biology},
  year={1993},
  volume={123},
  pages={417 - 429}
}
The 43-kD growth-associated protein (GAP-43) is a major protein kinase C (PKC) substrate of growing axons, and of developing nerve terminals and glial cells. It is a highly hydrophilic protein associated with the cortical cytoskeleton and membranes. In neurons it is rapidly transported from the cell body to growth cones and nerve terminals, where it accumulates. To define the role of GAP-43 in neurite outgrowth, we analyzed neurite regeneration in cultured dorsal root ganglia (DRG) neurons that… CONTINUE READING