Corpus ID: 209376841

Depletion interactions modulate coupled folding and binding in crowded environments.

@inproceedings{Zosel2019DepletionIM,
  title={Depletion interactions modulate coupled folding and binding in crowded environments.},
  author={Franziska Zosel and Andrea Soranno and Daniel Nettels and Benjamin Schuler},
  year={2019}
}
  • Franziska Zosel, Andrea Soranno, +1 author Benjamin Schuler
  • Published 2019
  • Chemistry, Physics
  • Intrinsically disordered proteins (IDPs) abound in cellular regulation. Their interactions are often transitory and highly sensitive to salt concentration and posttranslational modifications. However, little is known about the effect of macromolecular crowding on the kinetics and stability of the interactions of IDPs with their cellular targets. Here, we investigate the influence of crowding on the coupled folding and binding between two IDPs, using polyethylene glycol as a crowding agent… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Figures from this paper.

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 74 REFERENCES

    Intrinsically disordered proteins: emerging interaction specialists.

    VIEW 3 EXCERPTS
    HIGHLY INFLUENTIAL

    Affinity of IDPs to their targets is modulated by ion-specific changes in kinetics and residual structure.

    VIEW 1 EXCERPT