Depletion and mutation of topoisomerase II in animal cells.


Eukaryotic type II topoisomerases (Topo II) are implicated in a wide range of cellular processes. Cells in which Topo II protein has been specifically depleted or mutated provide powerful systems for analysing the normal in vivo functions of Topo II proteins and for assessing their roles in various chemotherapy regimens. Summarised here are the ways in… (More)
DOI: 10.1007/978-1-60761-340-4_19


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