Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis.

@article{Mallucci2003DepletingNP,
  title={Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis.},
  author={Giovanna R Mallucci and Andrew W. L. Dickinson and Jacqueline M. Linehan and P. -C. Kl{\"o}hn and Sebastian Brandner and John Collinge},
  journal={Science},
  year={2003},
  volume={302 5646},
  pages={871-4}
}
The mechanisms involved in prion neurotoxicity are unclear, and therapies preventing accumulation of PrPSc, the disease-associated form of prion protein (PrP), do not significantly prolong survival in mice with central nervous system prion infection. We found that depleting endogenous neuronal PrPc in mice with established neuroinvasive prion infection reversed early spongiform change and prevented neuronal loss and progression to clinical disease. This occurred despite the accumulation of… CONTINUE READING
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