Depleted dopamine in gastric cancer tissues: dopamine treatment retards growth of gastric cancer by inhibiting angiogenesis.

@article{Chakroborty2004DepletedDI,
  title={Depleted dopamine in gastric cancer tissues: dopamine treatment retards growth of gastric cancer by inhibiting angiogenesis.},
  author={Debanjan Chakroborty and Chandrani Sarkar and Rita Basu Mitra and Samir Banerjee and Partha Sarathi Dasgupta and Sujit Basu},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2004},
  volume={10 13},
  pages={4349-56}
}
PURPOSE It has been recently shown that the catecholamine neurotransmitter dopamine (DA) strongly and selectively inhibits vascular permeability factor/vascular endothelial growth factor (VPF/VEGF)-induced angiogenesis. Gastric cancer is highly angiogenic and is dependent on VEGF for its growth and progression. Because substantial amounts of DA present in normal stomach tissues has been implicated in several gastric functions, we therefore investigated the role, if any, of this neurotransmitter… CONTINUE READING
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Dopamine in Gastric Cancer Research

  • Chandrani Sarkar, Rita Basu Mitra
  • Katzung BG, editor. Basic and clinical…
  • 2004
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