Depigmentation with tert-butyl hydroquinone using black guinea pigs.

  title={Depigmentation with tert-butyl hydroquinone using black guinea pigs.},
  author={Emily Patrick and Daland R. Juberg and Joseph O'Donoghue and Howard Ira Maibach},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  volume={37 2-3},
tert-Butyl hydroquinone (TBHQ) has important and functional uses in consumer and commercial applications, some of which involve human exposure primarily through dermal contact. To assist in the safety evaluation of TBHQ, this study was conducted to determine whether TBHQ would produce changes in skin pigmentation after repeated dermal application to black guinea pigs. Hydroquinone (HQ) and hydroquinone monomethyl ether (HQMME) were used as positive controls. TBHQ and HQ were tested at… CONTINUE READING