Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents.

@article{Knebel1996DephosphorylationOR,
  title={Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents.},
  author={Axel Knebel and Hans Jobst Rahmsdorf and Axel Ullrich and Peter A. Herrlich},
  journal={The EMBO journal},
  year={1996},
  volume={15 19},
  pages={5314-25}
}
Several non-physiologic agents such as radiation, oxidants and alkylating agents induce ligand-independent activation of numerous receptor tyrosine kinases (RTKs) and of protein tyrosine kinases at the inner side of the plasma membrane (e.g. Dévary et al., 1992; Sachsenmaier et al., 1994; Schieven et al., 1994; Coffer et al., 1995). Here we show additional evidence for the activation of epidermal growth factor receptor (EGFR), and we show activation of v-ErbB, ErbB2 and platelet-derived growth… CONTINUE READING
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