Dephosphorylation of microtubule-associated protein tau by protein phosphatase 5.

  title={Dephosphorylation of microtubule-associated protein tau by protein phosphatase 5.},
  author={C X Gong and Fei Liu and Guoxin Wu and Sandra S. Rossie and Jerzy Wegiel and Liang Li and Inge Grundke-Iqbal and Khalid Iqbal},
  journal={Journal of neurochemistry},
  volume={88 2},
Protein phosphatase 5 (PP5) is a 58-kDa novel phosphoseryl/phosphothreonyl protein phosphatase. It is ubiquitously expressed in all mammalian tissues examined, with a high level in the brain, but little is known about its physiological substrates. We found that this phosphatase dephosphorylated recombinant tau phosphorylated with cAMP-dependent protein kinase and glycogen synthase kinase-3beta, as well as abnormally hyperphosphorylated tau isolated from brains of patients with Alzheimer's… CONTINUE READING


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