Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria.

@article{Cereghetti2008DephosphorylationBC,
  title={Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria.},
  author={Grazia M. Cereghetti and Alessandra Stangherlin and Olga Martins de Brito and Chiu Chin Chang and Craig Blackstone and Paolo Bernardi and Luca Scorrano},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 41},
  pages={
          15803-8
        }
}
Changes in mitochondrial morphology that occur during cell cycle, differentiation, and death are tightly regulated by the balance between fusion and fission processes. Excessive fragmentation can be caused by inhibition of the fusion machinery and is a common consequence of dysfunction of the organelle. Here, we show a role for calcineurin-dependent translocation of the profission dynamin related protein 1 (Drp1) to mitochondria in dysfunction-induced fragmentation. When mitochondrial… CONTINUE READING
Highly Influential
This paper has highly influenced 37 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Highly Cited
This paper has 541 citations. REVIEW CITATIONS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 335 extracted citations

Mitochondrial Dynamics as a Therapeutic Target for Treating Cardiac Diseases.

Handbook of experimental pharmacology • 2017
View 4 Excerpts
Highly Influenced

542 Citations

020406080'10'12'14'16'18
Citations per Year
Semantic Scholar estimates that this publication has 542 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 33 references