Dephosphorylation and activation of the T cell tyrosine kinase pp56lck by the leukocyte common antigen (CD45).

@article{Mustelin1990DephosphorylationAA,
  title={Dephosphorylation and activation of the T cell tyrosine kinase pp56lck by the leukocyte common antigen (CD45).},
  author={Tomas M. Mustelin and Amnon Altman},
  journal={Oncogene},
  year={1990},
  volume={5 6},
  pages={809-13}
}
pp56lck, encoded by the lck proto-oncogene, is a non-receptor tyrosine protein kinase (TPK) found in all T lymphocytes. A significant fraction of pp56lck is tightly associated with the cytoplasmic domains of CD4 and CD8 glycoproteins, suggesting an important role for it in thymic development and T cell activation. We have studied the regulation of the tyrosine kinase activity of pp56lck and found recently that it becomes rapidly activated in isolated T cell membranes by an endogenous mechanism… CONTINUE READING
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