Depersonalization disorder: Effects of caffeine and response to pharmacotherapy

@article{Stein1989DepersonalizationDE,
  title={Depersonalization disorder: Effects of caffeine and response to pharmacotherapy},
  author={Murray B. Stein and Thomas W Uhde},
  journal={Biological Psychiatry},
  year={1989},
  volume={26},
  pages={315-320}
}

Depersonalization disorder: pharmacological approaches

  • M. Sierra
  • Psychology, Biology
    Expert review of neurotherapeutics
  • 2008
A number of studies suggest that opioid receptor antagonists such as naltrexone and naloxone are useful in at least a subgroup of patients, and those neurotransmitter systems of relevance to depersonalization are known to play important inhibitory roles in the regulation of the stress response.

Feeling unreal: 30 cases of DSM-III-R depersonalization disorder.

This study supports the conceptualization of depersonalization disorder as a distinct disorder with a characteristic course that is independent of mood, anxiety, and personality symptoms, and suggests a subtle relationship may exist between childhood trauma and depersonALization disorder that merits further investigation.

Understanding and treating depersonalisation disorder

Depersonalisation disorder involves an unpleasant, chronic and disabling alteration in the experience of self and environment. In addition to these classic features of depersonalisation and

Zolpidem Induces Depersonalization and Derealization Symptoms: A Case Report

Medications and medical as well as psychiatric conditions, which are associated with causing symptoms of depersonalization, are reported here and the postulated pathogenesis by which some of these drugs induced depersonALization symptoms is also discussed.

Medication-associated Depersonalization Symptoms: Report of Transient Depersonalization Symptoms Induced by Minocycline

Medication-associated depersonalization symptoms typically resolve once the inducing drug has been withdrawn, and the postulated pathogenesis by which some of these drugs induced depersonALization symptoms is discussed.

Instrument to assess depersonalization‐derealization in panic disorder

A 28‐item Depersonalization‐Derealization Inventory was found to possess good reliability and validity and may be appropriate as a brief screen in patients with panic disorder.

Dissociative Disorders and Conversion Disorders

The terms “dissociation” and “desaggregation” (disaggregation) were coined by Pierre Janet (1889). Janet viewed the mental life of the individual as an aggregate of mental elements, which he

Pharmacotherapy for dissociative disorders: A systematic review

Lamotrigine in the immediate treatment of outpatients with depersonalization disorder without psychiatric comorbidity: randomized, double-blind, placebo-controlled study.

This is believed to be the first double-blind placebo-controlled randomization study to test the efficacy of lamotrigine in the management of outpatients with DPDs and the results need to be replicated in a larger study group.

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The present position is that iproniazid is providing an enormous stimulus to the development of a rational chemotherapy of depression, and the use of the drug in clinical practice should always be carefully considered, and, if used, accompanied by weekly serum G.O.T. estimations.

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A psychotherapeutic approach to the treatment of depersonalization disorder enables the patient to drop dissociation as a defense against overly vigorous scrutiny of a "self," which is felt to be inadequate when compared to highly demanding standards set by parents.

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The results suggest that some panic disorder patients may have abnormalities in neuronal systems involving adenosine, and patients with anxiety disorders may benefit by avoiding caffeine-containing foods and beverages.

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It is important to understand the pathophysiology and biological correlates of “spontaneous” or “unprovoked” panic attacks.