Depersonalization disorder: Effects of caffeine and response to pharmacotherapy

  title={Depersonalization disorder: Effects of caffeine and response to pharmacotherapy},
  author={Murray B. Stein and Thomas W Uhde},
  journal={Biological Psychiatry},

Depersonalization disorder: pharmacological approaches

  • M. Sierra
  • Psychology, Biology
    Expert review of neurotherapeutics
  • 2008
A number of studies suggest that opioid receptor antagonists such as naltrexone and naloxone are useful in at least a subgroup of patients, and those neurotransmitter systems of relevance to depersonalization are known to play important inhibitory roles in the regulation of the stress response.

Feeling unreal: 30 cases of DSM-III-R depersonalization disorder.

This study supports the conceptualization of depersonalization disorder as a distinct disorder with a characteristic course that is independent of mood, anxiety, and personality symptoms, and suggests a subtle relationship may exist between childhood trauma and depersonALization disorder that merits further investigation.

Understanding and treating depersonalisation disorder

Depersonalisation disorder involves an unpleasant, chronic and disabling alteration in the experience of self and environment. In addition to these classic features of depersonalisation and

Zolpidem Induces Depersonalization and Derealization Symptoms: A Case Report

Medications and medical as well as psychiatric conditions, which are associated with causing symptoms of depersonalization, are reported here and the postulated pathogenesis by which some of these drugs induced depersonALization symptoms is also discussed.

Medication-associated Depersonalization Symptoms: Report of Transient Depersonalization Symptoms Induced by Minocycline

Medication-associated depersonalization symptoms typically resolve once the inducing drug has been withdrawn, and the postulated pathogenesis by which some of these drugs induced depersonALization symptoms is discussed.

Instrument to assess depersonalization‐derealization in panic disorder

A 28‐item Depersonalization‐Derealization Inventory was found to possess good reliability and validity and may be appropriate as a brief screen in patients with panic disorder.

Dissociative Disorders and Conversion Disorders

The terms “dissociation” and “desaggregation” (disaggregation) were coined by Pierre Janet (1889). Janet viewed the mental life of the individual as an aggregate of mental elements, which he

Pharmacotherapy for dissociative disorders: A systematic review

Lamotrigine in the immediate treatment of outpatients with depersonalization disorder without psychiatric comorbidity: randomized, double-blind, placebo-controlled study.

This is believed to be the first double-blind placebo-controlled randomization study to test the efficacy of lamotrigine in the management of outpatients with DPDs and the results need to be replicated in a larger study group.



Depersonalization and agoraphobia associated with marijuana use.

  • C. Moran
  • Psychology, Medicine
    The British journal of medical psychology
  • 1986
The standard cognitive-behavioural treatment programme required modification to account for the intensity of the fear of depersonalization in the cases, and data obtained before and after treatment indicated the cases were slightly more severe than clinic patients.

The Phobic Anxiety-depersonalization Syndrome [Abridged]

The present position is that iproniazid is providing an enormous stimulus to the development of a rational chemotherapy of depression, and the use of the drug in clinical practice should always be carefully considered, and, if used, accompanied by weekly serum G.O.T. estimations.

Depersonalization Phenomena in Psychiatric Patients

Depersonalization has been reported in epilepsy, after drug ingestion, encephalitis, hysteria, manic depression, and schizophrenia, as well as in various neurotic patients, and has also been noted in normals, but usually after emotional shock or physical exhaustion.

Phenomenological Overlap of Multiple Personality Disorder and Obsessive‐Compulsive Disorder

There appears to be a phenomenological overlap between multiple personality disorder and some cases of obsessive-compulsive disorder and Obsessive patients with prominent dissociative features may be a psychologically and biologically distinct subgroup.

The psychotherapeutic treatment of depersonalization disorder.

  • E. Torch
  • Psychology
    The Hillside journal of clinical psychiatry
  • 1987
A psychotherapeutic approach to the treatment of depersonalization disorder enables the patient to drop dissociation as a defense against overly vigorous scrutiny of a "self," which is felt to be inadequate when compared to highly demanding standards set by parents.

Alprazolam in panic disorder and agoraphobia: results from a multicenter trial. I. Efficacy in short-term treatment.

Alprazolam was found to be effective and well tolerated in patients with agoraphobia with panic attacks and panic disorder and significantly more placebo recipients subsequently dropped out of the trial, primarily citing ineffectiveness of placebo as the reason.

Treatment of panic disorder and agoraphobia with clonazepam.

This study suggests that clonazepam, like alprazolam, may be effective in blocking panic attacks and suggests a possible common mechanism for the two drugs as high-potency benzodiazepines.

Desipramine: A Possible Treatment for Depersonalization Disorder*

The successful treatment of a case with desipramine is reported and it is suggested that, because there is a link between depersonalization and anxiety disorders, tricyclic antidepressants may prove effective for depERSONalization.

Increased anxiogenic effects of caffeine in panic disorders.

The results suggest that some panic disorder patients may have abnormalities in neuronal systems involving adenosine, and patients with anxiety disorders may benefit by avoiding caffeine-containing foods and beverages.

Caffeine Model of Panic

It is important to understand the pathophysiology and biological correlates of “spontaneous” or “unprovoked” panic attacks.