Depersonalisation Disorder

  title={Depersonalisation Disorder},
  author={Daphne Simeon},
  journal={CNS Drugs},
Depersonalisation disorder is characterised by prominent depersonalisation and often derealisation, without clinically notable memory or identity disturbances. The disorder has an approximately 1: 1 gender ratio with onset at around 16 years of age. The course of the disorder is typically long term and often continuous. Mood, anxiety and personality disorders are often comorbid with depersonalisation disorder but none predict symptom severity.The most common immediate precipitants of the… 

Depersonalization and personality in panic disorder.

Illness perceptions in depersonalization disorder: testing an illness attribution model

Depersonalization disorder (DPD) remains poorly understood and controversial in terms of diagnosis and treatment. Little is known about the cognitive representation of this disorder. In this study,

Fluoxetine therapy in depersonalisation disorder: Randomised controlled trial

Fluoxetine was not efficacious in treating depersonalisation disorder, despite the commonly reported clinical use of serotonin reuptake inhibitors for this condition.

An Open Trial of Naltrexone in the Treatment of Depersonalization Disorder

There was an average 30% reduction of symptoms with treatment, as measured by 3 validated dissociation scales, and these findings are potentially promising in a highly treatment-refractory disorder for which no treatment guidelines exist and warrant a randomized controlled trial.

Somatoform Dissociation in Depersonalization Disorder

Somatoform dissociation is modest in DPD, and the SDQ is a weak instrument for the screening of dissociation in this disorder, detecting only one third of the sample when using the traditional SDQ cutoff score of 30.

The Relationship between Interpersonal Abuse and Depersonalization Experiences

Depersonalization is a common psychiatric symptom that remains understudied amongst Latino/Hispanic populations. There is evidence that depersonalization is relatively common among persons with a

[Depersonalisation/derealization - clinical picture, diagnostics and therapy].

  • M. MichalM. Beutel
  • Psychology, Medicine
    Zeitschrift fur Psychosomatische Medizin und Psychotherapie
  • 2009
There is a considerable lack of empirical research onDP-DR with respect to the health-care situation of depersonalized patients and with regard to treatment options, and it is suggested that symptoms of DP-DR indicate disease severity and negatively predict therapy outcome.

Trapped in a Glass Bell Jar: Neural Correlates of Depersonalization and Derealization in Subjects at Clinical High-Risk of Psychosis and Depersonalization–Derealization Disorder

This study shows that DP/DR symptoms are frequently found in CHR subjects and indicates that there may be divergent pathophysiological mechanisms—decreased neuronal activity in the orbitofrontal cortex, but increased activity within the caudate nucleus—leading to a final common pathway with similar psychopathological symptoms.



Feeling unreal: a depersonalization disorder update of 117 cases.

The characteristics of depersonalization disorder found in this sample, the largest described to date, are in good accord with previous literature, and the study highlights the need for novel therapeutic approaches to treat depersonALization disorder.

Depersonalisation disorder: clinical features of 204 cases

Depersonalisation disorder is a recognisable clinical entity but appears to have significant comorbidity with anxiety and depression and research into its aetiology and treatment is warranted.

Feeling unreal: 30 cases of DSM-III-R depersonalization disorder.

This study supports the conceptualization of depersonalization disorder as a distinct disorder with a characteristic course that is independent of mood, anxiety, and personality symptoms, and suggests a subtle relationship may exist between childhood trauma and depersonALization disorder that merits further investigation.

Autonomic response in depersonalization disorder.

The fact that patients with depersonalization disorder respond earlier to a startling noise suggests that they are in a heightened state of alertness and that the reduced response to unpleasant stimuli is caused by a selective inhibitory mechanism on emotional processing.

The spectrum of organic depersonalization: a review plus four new cases.

The authors present 4 new cases of depersonalization in patients with an underlying organic condition, along with 47 cases from the literature in which the available information permits diagnosis of organic depersonality, and suggested left-sided temporal lobe dysfunction and anxiety are suggested as factors in the development of depERSONalization.

Depersonalization disorder: thinking without feeling