Depending on the stage of hepatosteatosis, p53 causes apoptosis primarily through either DRAM-induced autophagy or BAX

@inproceedings{Liu2013DependingOT,
  title={Depending on the stage of hepatosteatosis, p53 causes apoptosis primarily through either DRAM-induced autophagy or BAX},
  author={Kai Liu and Jinli Lou and Tao Wen and Jiming Yin and Bin Xu and Wei Ding and Anna Wang and Daojie Liu and Chao Zhang and Dexi X Chen and Ning Li},
  booktitle={Liver international : official journal of the International Association for the Study of the Liver},
  year={2013}
}
BACKGROUND & AIMS Apoptosis mediated by p53 plays a pathological role in the progression of hepatosteatosis. It is noteworthy that p53 can promote the expression of damage-regulated autophagy modulator (DRAM), an inducer of autophagy-mediated apoptosis. However, the relationship between p53-mediated apoptosis and autophagy in hepatosteatosis remains elusive. This study aimed to examine how p53 orchestrates autophagy and apoptosis to affect hepatosteatosis. METHODS HepG2 cells were treated… CONTINUE READING
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Cytokeratin-18 and hyaluronic acid levels predict liver fibrosis in Liver International

DM Lebensztejn, A Wierzbicka, P Socha
The Authors. Liver International published by John Wiley & Sons Ltd • 2013

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