Dependent Translation Initiation in Breast Cancer Cells − Metformin Inhibits Mammalian Target of Rapamycin

@inproceedings{Dowling2007DependentTI,
  title={Dependent Translation Initiation in Breast Cancer Cells − Metformin Inhibits Mammalian Target of Rapamycin},
  author={Ryan J. O. Dowling and Mahvash Zakikhani and Ivan George Fantus and Michael N. Pollak and Nahum Sonenberg},
  year={2007}
}
Metformin is used for the treatment of type 2 diabetes because of its ability to lower blood glucose. The effects of metformin are explained by the activation of AMP-activated protein kinase (AMPK), which regulates cellular energy metabolism. Recently, we showed that metformin inhibits the growth of breast cancer cells through the activation of AMPK. Here… CONTINUE READING