Dependency of renal blood flow on prostaglandin synthesis in the dog.

@article{Lonigro1973DependencyOR,
  title={Dependency of renal blood flow on prostaglandin synthesis in the dog.},
  author={Andrew J. Lonigro and H D Itskovitz and K Crowshaw and J C Mcgiff},
  journal={Circulation research},
  year={1973},
  volume={32 6},
  pages={712-7}
}
Inhibition of prostaglandin synthesis in chloralose-anesthetized dogs reduced renal blood flow, and this reduction closely correlated (r = 0.92, P<0.01) with a decline in the renal efflux of a substance having the properties of PGE2. We used solvent extraction and thin-layer chromatography coupled with parallel bioassay to identify and assay the PGEand PGF-like substances (expressed as PGE2 and PGF2a equivalents). Either of two antunflaiunatory acids, indomethacin or meclofenamate, that… CONTINUE READING