Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells.

@article{Vaeth2012DependenceON,
  title={Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells.},
  author={Martin Vaeth and Ulrike Schliesser and Gerd M{\"u}ller and Sonja Reissig and Kazuki Satoh and Andrea Tuettenberg and Helmut Jonuleit and Ari Waisman and Martin R. Mueller and E. Serfling and B Sawitzki and Friederike Berberich-Siebelt},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 40},
  pages={
          16258-63
        }
}
Several lines of evidence suggest nuclear factor of activated T-cells (NFAT) to control regulatory T cells: thymus-derived naturally occurring regulatory T cells (nTreg) depend on calcium signals, the Foxp3 gene harbors several NFAT binding sites, and the Foxp3 (Fork head box P3) protein interacts with NFAT. Therefore, we investigated the impact of NFAT on Foxp3 expression. Indeed, the generation of peripherally induced Treg (iTreg) by TGF-β was highly dependent on NFAT expression because the… CONTINUE READING
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