Dependence on blood acetate concentration of the metabolic effects of ethanol in perfused rat liver.

@article{Topping1984DependenceOB,
  title={Dependence on blood acetate concentration of the metabolic effects of ethanol in perfused rat liver.},
  author={David L. Topping and Aaron Snoswell and Gregory Storer and R C Fishlock and R P Trimble},
  journal={Biochimica et biophysica acta},
  year={1984},
  volume={800 1},
  pages={103-5}
}
In livers from fed rats perfused with recirculating blood, infusion of ethanol produced an inhibition of ketogenesis followed by substantially increased production. Perfusate lactate concentrations fell markedly following the increase in ketone body formation. In these experiments perfusate acetate rose continuously, reaching a concentration of 10 mM at 70 min, while in a control liver concentrations remained very low. During non-recirculating perfusion with 3 mM acetate there was output of… CONTINUE READING