Dependence of plasmodial glutathione metabolism on the host cell

  title={Dependence of plasmodial glutathione metabolism on the host cell},
  author={James R. Eckman and John W. Eaton},
ONE inherited alteration of human red cell metabolism—quantitative deficiency of the X-linked enzyme glucose-6-phosphate dehydrogenase (G-6-PD)—has attained high frequency in many areas of endemic malaria and may protect against fulminant Plasmodium falciparum in some unknown fashion1–5. G-6-PD catalyses the first step of the pentose phosphate pathway which provides reduced NADPH necessary for conversion of oxidised to reduced glutathione (GSSG→GSH)6. Erythrocytes deficient in G-6-PD are… CONTINUE READING

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