Dependence of nucleotide substitutions on Ung2, Msh2, and PCNA-Ub during somatic hypermutation

@inproceedings{Krijger2009DependenceON,
  title={Dependence of nucleotide substitutions on Ung2, Msh2, and PCNA-Ub during somatic hypermutation},
  author={Peter H. L. Krijger and Petra Langerak and Paul C.M. van den Berk and Heinz Jacobs},
  booktitle={The Journal of experimental medicine},
  year={2009}
}
During somatic hypermutation (SHM), B cells introduce mutations into their immunoglobulin genes to generate high affinity antibodies. Current models suggest a separation in the generation of G/C transversions by the Ung2-dependent pathway and the generation of A/T mutations by the Msh2/ubiquitinated proliferating cell nuclear antigen (PCNA-Ub)-dependent pathway. It is currently unknown whether these pathways compete to initiate mutagenesis and whether PCNA-Ub functions downstream of Ung2… CONTINUE READING