Dependence of neurotrophic factor activation of Trk tyrosine kinase receptors on cellular sialidase.

@article{Woronowicz2007DependenceON,
  title={Dependence of neurotrophic factor activation of Trk tyrosine kinase receptors on cellular sialidase.},
  author={Alicja Woronowicz and Schammim Ray Amith and Kristof De Vusser and Wouter Laroy and Roland Contreras and Sameh Basta and Myron R Szewczuk},
  journal={Glycobiology},
  year={2007},
  volume={17 1},
  pages={10-24}
}
A direct link between receptor glycosylation and activation following natural ligand interaction has not been observed. Here, we discover a membrane sialidase-controlling mechanism that depends on ligand binding to its receptor to induce enzyme activity which targets and desialylates the receptor and, consequently, causes the induction of receptor dimerization and activation. We also identify a specific sialyl alpha-2,3-linked beta-galactosyl sugar residue of TrkA tyrosine kinase receptor… CONTINUE READING

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