Dependence of misonidazole binding on factors associated with hypoxic metabolism.

Abstract

The binding of misonidazole (MISO) to macromolecules in hypoxic cells is believed to require metabolic reduction. Several factors in the cells' environment, such as pH, glucose, lactate and MISO concentration could affect the capacity of metabolic reduction. Modulation of the binding of MISO by these factors was studied by exposing exponential EMT6/Ro cells… (More)
DOI: 10.1038/bjc.1987.212

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