Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4.

@article{Peled1999DependenceOH,
  title={Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4.},
  author={Amnon Peled and Isabelle Petit and Orit Kollet and Michal Magid and Tatyana Ponomaryov and Tamara Byk and Arnon Nagler and Herzl Ben-Hur and Amira Many and Leonard Shultz and Ofer Lider and Ronen Alon and Dov Zipori and Tsvee Lapidot},
  journal={Science},
  year={1999},
  volume={283 5403},
  pages={845-8}
}
Stem cell homing and repopulation are not well understood. The chemokine stromal cell-derived factor-1 (SDF-1) and its receptor CXCR4 were found to be critical for murine bone marrow engraftment by human severe combined immunodeficient (SCID) repopulating stem cells. Treatment of human cells with antibodies to CXCR4 prevented engraftment. In vitro CXCR4-dependent migration to SDF-1 of CD34+CD38-/low cells correlated with in vivo engraftment and stem cell function. Stem cell factor and… CONTINUE READING
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