Dependence of glycine conjugation on availability of glycine: role of the glycine cleavage system.

@article{Gregus1993DependenceOG,
  title={Dependence of glycine conjugation on availability of glycine: role of the glycine cleavage system.},
  author={Zolt{\'a}n Gregus and T Fekete and Ferenc Varga and Curtis D. Klaassen},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={1993},
  volume={23 2},
  pages={141-53}
}
1. Glycine conjugation of benzoic acid was investigated in anaesthetized rats by measuring the disappearance of benzoate from blood, and the appearance of benzoylglycine in blood and urine. 2. Administration of glycine (1-10 mmol/kg,i.v.) increased the capacity of benzoylglycine formation in a dose-dependent fashion, with a maximal rate (8.1 mumol/kg per min) occurring after administration of 5 mmol/kg glycine. The normal endogenous glycine supply (1.7 mM in liver) permits glycine conjugation… CONTINUE READING