Dependence of epistasis on environment and mutation severity as revealed by in silico mutagenesis of phage t7.

@article{You2002DependenceOE,
  title={Dependence of epistasis on environment and mutation severity as revealed by in silico mutagenesis of phage t7.},
  author={Lingchong You and John Yin},
  journal={Genetics},
  year={2002},
  volume={160 4},
  pages={1273-81}
}
Understanding how interactions among deleterious mutations affect fitness may shed light on a variety of fundamental biological phenomena, including the evolution of sex, the buffering of genetic variations, and the topography of fitness landscapes. It remains an open question under what conditions and to what extent such interactions may be synergistic or… CONTINUE READING