Dependence of axolemmal differentiation on contact with glial cells in chronically demyelinated lesions of cat spinal cord

@article{Rosenbluth1985DependenceOA,
  title={Dependence of axolemmal differentiation on contact with glial cells in chronically demyelinated lesions of cat spinal cord},
  author={J. H. Rosenbluth and Jung-Hwa Tao-Cheng and William F Blakemore},
  journal={Brain Research},
  year={1985},
  volume={358},
  pages={287-302}
}
Chronically demyelinated lesions of cat dorsal columns were created by focal injection of the glial toxin ethidium bromide. Freeze-fracture studies show that the center of the lesion, which is devoid of glial cells and processes, contains axons having neither node-like nor paranodal-type membrane specializations. Near the margin of the lesion, however, where axons are in contact with glial cells, the axolemma sometimes displays focal accumulations of E- and P-face particles resembling those at… CONTINUE READING

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