Dependence of adrenalectomy-induced sodium appetite on the action of angiotensin II in the brain of the rat.

@article{Sakai1990DependenceOA,
  title={Dependence of adrenalectomy-induced sodium appetite on the action of angiotensin II in the brain of the rat.},
  author={Randall R. Sakai and Alan N. Epstein},
  journal={Behavioral neuroscience},
  year={1990},
  volume={104 1},
  pages={167-76}
}
Adrenalectomized rats express a robust sodium appetite that is accompanied by high levels of blood-borne angiotensin II and is caused by angiotensin II of cerebral origin. Blood-borne angiotensin II is elevated in rats consuming NaCl after adrenalectomy, and plasma angiotensin II concentrations are increased further when the animals cannot drink a NaCl solution. These phenomena are the result of the pathological removal of aldosterone, because replacement therapy returned both sodium intake and… CONTINUE READING