Dependence of adenovirus infectivity on length of the fiber shaft domain.

@article{Shayakhmetov2000DependenceOA,
  title={Dependence of adenovirus infectivity on length of the fiber shaft domain.},
  author={Dmitry M. Shayakhmetov and Andr{\'e} Lieber},
  journal={Journal of virology},
  year={2000},
  volume={74 22},
  pages={10274-86}
}
One of the objectives in adenovirus (Ad) vector development is to target gene delivery to specific cell types. Major attention has been given to modification of the Ad fiber knob, which is thought to determine virus tropism. However, among the human Ad serotypes with different tissue tropisms, not only the knob but also the length of the fiber shaft domain varies significantly. In this study we attempted to delineate the role of fiber length in coxsackievirus-adenovirus receptor (CAR)- and non… CONTINUE READING

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