Dependence of a human squamous carcinoma and associated paraneoplastic syndromes on the epidermal growth factor receptor pathway in nude mice.

@article{Yoneda1991DependenceOA,
  title={Dependence of a human squamous carcinoma and associated paraneoplastic syndromes on the epidermal growth factor receptor pathway in nude mice.},
  author={Toshiyuki Yoneda and Mª. M. Alsina and Kazuya Watatani and F. Bellot and Joseph Schlessinger and Gregory R. Mundy},
  journal={Cancer research},
  year={1991},
  volume={51 9},
  pages={
          2438-43
        }
}
Increased levels of epidermal growth factor receptor (EGFR) have been shown on squamous cell carcinomas. Recently, we described a squamous cell carcinoma (MH-85) derived from the oral cavity which was associated with several paraneoplastic syndromes including hypercalcemia and cachexia. This tumor induced the same paraneoplastic syndromes in nude mice (BALB/c, nu/nu, male, 4-6 weeks old). Scatchard analysis revealed that there are two classes of EGFR in MH-85. The dissociation constant and… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 46 REFERENCES

Detection of transforming growth factor-a messenger RNA in normal and chemically transformed hamster oral epithelium by in situ hybridization

Chang, L-C, +6 authors D.T.W. Wong
  • Cancer Res.,
  • 1989
VIEW 1 EXCERPT