Dependence of Joint Development on Limb Motion : an In-vitro Model of Knee Morphogenesis in the Chick Embryo

  • Published 2002
Introduction: Histologic and morphologic studies have demonstrated that embryonic motion is required for normal diarthrodial joint development. Chicks paralyzed during embryogenesis develop arthrogrypotic joints . However, controversy exists as to the extent that joint morphogenesis is determined by genetic programming and modulated by mechanical factors… CONTINUE READING