Dependence network modeling for biomarker identification

  title={Dependence network modeling for biomarker identification},
  author={Peng Qiu and Z. Jane Wang and K. J. Ray Liu and Zhang-Zhi Hu and Cathy H. Wu},
  volume={23 2},
MOTIVATION Our purpose is to develop a statistical modeling approach for cancer biomarker discovery and provide new insights into early cancer detection. We propose the concept of dependence network, apply it for identifying cancer biomarkers, and study the difference between the protein or gene samples from cancer and non-cancer subjects based on mass-spectrometry (MS) and microarray data. RESULTS Three MS and two gene microarray datasets are studied. Clear differences are observed in the… CONTINUE READING


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Cancer genomics, proteomics, and clinic applications

  • X. Steve Fu, Chien-an Hu, Jie Chen, Z. Jane Wang, K. J. Ray Liu
  • Genomic Signal Processing and Statistics, Hindawi…
  • 2005

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