Dependence and independence of [PSI(+)] and [PIN(+)]: a two-prion system in yeast?

  title={Dependence and independence of [PSI(+)] and [PIN(+)]: a two-prion system in yeast?},
  author={Irina L. Derkatch and Michael E. Bradley and Sherie V Masse and Sergey P Zadorsky and Gennady V. Polozkov and Sergey G. Inge-Vechtomov and Susan W Liebman},
  journal={The EMBO journal},
  volume={19 9},
The [PSI(+)] prion can be induced by overproduction of the complete Sup35 protein, but only in strains carrying the non-Mendelian [PIN(+)] determinant. Here we demonstrate that just as [psi (-)] strains can exist as [PIN(+)] and [pin(-)] variants, [PSI(+)] can also exist in the presence or absence of [PIN(+)]. [PSI(+)] and [PIN(+)] tend to be cured together, but can be lost separately. [PSI(+)]-related phenotypes are not affected by [PIN(+)]. Thus, [PIN(+)] is required for the de novo formation… CONTINUE READING