Deoxysugar Transfer during Chromomycin A3 Biosynthesis in Streptomyces griseus subsp. griseus: New Derivatives with Antitumor Activity

@article{Menndez2006DeoxysugarTD,
  title={Deoxysugar Transfer during Chromomycin A3 Biosynthesis in Streptomyces griseus subsp. griseus: New Derivatives with Antitumor Activity},
  author={Nuria Men{\'e}ndez and Md. Nur-E-Alam and Carsten Fischer and Alfredo F Bra{\~n}a and Jos{\'e} A Salas and J{\"u}rgen Rohr and Carmen M{\'e}ndez},
  journal={Applied and Environmental Microbiology},
  year={2006},
  volume={72},
  pages={167 - 177}
}
ABSTRACT Chromomycin A3 is an antitumor drug produced by Streptomyces griseus subsp. griseus. It consists of a tricyclic aglycone with two aliphatic side chains and two O-glycosidically linked saccharide chains, a disaccharide of 4-O-acetyl-d-oliose (sugar A) and 4-O-methyl-d-oliose (sugar B), and a trisaccharide of d-olivose (sugar C), d-olivose (sugar D), and 4-O-acetyl-l-chromose B (sugar E). The chromomycin gene cluster contains four glycosyltransferase genes (cmmGI, cmmGII, cmmGIII, and… Expand
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