Deoxyribonucleic acid of Marek's disease virus in virus-induced tumors.

  title={Deoxyribonucleic acid of Marek's disease virus in virus-induced tumors.},
  author={Keyvan Nazerian and T. Lindahl and George Klein and Lucy F. Lee},
  journal={Journal of virology},
  volume={12 4},
DNA was extracted from [(3)H]thymidine-labeled Marek's disease virus (MDV) and purified by two cycles of CsCl gradient centrifugation in a fixed-angle rotor. The DNA was transcribed in vitro into (32)P-labeled complementary RNA (cRNA). MDV cRNA did not hybridize with DNA from chicken embryo fibroblast cultures or from chicken spleen, but hybridized efficiently with DNA from MDV particles or MDV-infected cell cultures. Five Marek's disease tumors from different chickens and different organs… CONTINUE READING


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