Deoxyribonucleic acid cytophometry on rat ovarian follicles kept in organ culture: the effects of gonadotropins and plasma from normal, hypergonadotropic menopausal, and hypogonadotropic women.


Pituitary FSH as well as urinary FSH were found to be potent stimulators of in vitro granulosa cell DNA synthesis in Wistar rat ovarian segments kept in organ culture. Optimal responses were reached at the highest concentration used (pituitary FSH, 5 mU/mL: urinary FSH, 50 mU/mL). hCG also appeared to be a potent stimulator (optimal response, 5 mU/mL). LH… (More)


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