Corpus ID: 21250133

Deoxyribonucleic acid biosynthesis in mitochondria. Studies on the incorporation of labeled precursors into mitochondrial deoxyribonucleic acid.

@article{Parsons1973DeoxyribonucleicAB,
  title={Deoxyribonucleic acid biosynthesis in mitochondria. Studies on the incorporation of labeled precursors into mitochondrial deoxyribonucleic acid.},
  author={P. Parsons and M. Simpson},
  journal={The Journal of biological chemistry},
  year={1973},
  volume={248 6},
  pages={
          1912-9
        }
}
Abstract Isolated rat liver mitochondria are capable of incorporating labeled deoxynucleoside triphosphates into DNA. The reaction is linear from 1 to 2 hours, is sensitive to high concentrations of actinomycin D, and requires oxidative phosphorylation and Mg2+. Deoxynucleoside triphosphates serve as better precursors than monophosphates, and a partial dependency on all four triphosphates is demonstrated. That the labeled product is DNA is shown by its complete lability to DNase, its complete… Expand
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