Deoxypodophyllotoxin induces G2/M cell cycle arrest and apoptosis in HeLa cells.

  title={Deoxypodophyllotoxin induces G2/M cell cycle arrest and apoptosis in HeLa cells.},
  author={Soon Young Shin and Yeonjoong Yong and Chang Gun Kim and Young Han Lee and Yoongho Lim},
  journal={Cancer letters},
  volume={287 2},
The natural flavolignan deoxypodophyllotoxin (DPPT) inhibits tubulin polymerization and induces cell cycle arrest at G(2)/M, followed by apoptosis. However, the precise mechanism of DPPT action is currently unknown. Here, we investigated the mechanism by which DPPT treatment of HeLa cervical carcinoma cells induces cell cycle arrest and apoptosis. We show that DPPT treatment inhibits cell viability in a dose-dependent manner and that this reduction in cell viability results from cell cycle… CONTINUE READING


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