Deoxynivalenol induces p38 interaction with the ribosome in monocytes and macrophages.

@article{Bae2008DeoxynivalenolIP,
  title={Deoxynivalenol induces p38 interaction with the ribosome in monocytes and macrophages.},
  author={Hee Kyong Bae and James J. Pestka},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2008},
  volume={105 1},
  pages={59-66}
}
Trichothecene mycotoxins rapidly induce p38-mediated gene expression and apoptosis in mononuclear phagocytes via a process known as the ribotoxic stress response. We hypothesized that the trichothecene deoxynivalenol (DON) induces interaction of p38 with the ribosome. Two models, U937 human monocytes and RAW 264.7 murine macrophages, were used to test this hypothesis based on their capacity to evoke rapid and robust p38 phosphorylation responses to DON. Following DON treatment of U937 cells… CONTINUE READING
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