Deoxynivalenol: mechanisms of action, human exposure, and toxicological relevance

@article{Pestka2010DeoxynivalenolMO,
  title={Deoxynivalenol: mechanisms of action, human exposure, and toxicological relevance},
  author={James J Pestka},
  journal={Archives of Toxicology},
  year={2010},
  volume={84},
  pages={663-679}
}
  • J. Pestka
  • Published 27 August 2010
  • Medicine
  • Archives of Toxicology
The trichothecene mycotoxin deoxynivalenol (DON) is produced in wheat, barley and corn following infestation by the fungus Fusarium in the field and during storage. Colloquially known as “vomitoxin” because of its emetic effects in pigs, DON has been associated with human gastroenteritis. Since DON is commonly detected in cereal foods, there are significant questions regarding the risks of acute poisoning and chronic effects posed to persons ingesting this trichothecene. A further challenge is… 
Deoxynivalenol: Mechanisms of action and its effects on various terrestrial and aquatic species.
  • J. Hooft, D. Bureau
  • Medicine
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2021
Advances in Deoxynivalenol Toxicity Mechanisms: The Brain as a Target
TLDR
Critical studies illustrating the central action of the toxin on the brain are summarized to suggest research perspectives in this field and to summarize critical studies illustrating this central action.
In vitro investigation of toxicological interactions between the fusariotoxins deoxynivalenol and zearalenone.
Intestinal toxicity of the masked mycotoxin deoxynivalenol-3-β-d-glucoside
TLDR
It is demonstrated that glucosylation of DON suppresses its ability to bind to the ribosome and decreases its intestinal toxicity.
Deoxynivalenol and Its Modified Forms: Are There Major Differences?
TLDR
Results show that 3ADON is less potent in inducing adverse effects on barrier integrity when compared to DON, whereas 15ADON appears to be slightly more potent than DON, which suggests that GOS are beneficial food additives in the protection of vulnerable segments of the human population against adverse effects of DON and its derivatives.
Effect of Deoxynivalenol and Other Type B Trichothecenes on the Intestine: A Review
TLDR
This review summarizes the current knowledge of the effects of DON and other TCTB on the intestine and suggests that intestinal epithelial cells are targets for deoxynivalenol and other Type B trichothecenes.
The Mycotoxin Deoxynivalenol Significantly Alters the Function and Metabolism of Bovine Kidney Epithelial Cells In Vitro
TLDR
The results here suggest that exposure of bovine cells to deoxynivalenol causes a decrease in protein synthesis with corresponding cellular accumulation of precursors, and that these responses contribute to reduced productivity in exposed cattle.
Mycotoxin Occurrence, Toxicity, and Detoxifying Agents in Pig Production with an Emphasis on Deoxynivalenol
TLDR
In summary, mycotoxins present challenges to pig production globally because of their increasing occurrences in recent years and their toxic effects impairing the health and growth of pigs.
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References

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Deoxynivalenol: Toxicology and Potential Effects on Humans
TLDR
Critical areas for future DON research include molecular mechanisms underlying toxicity, sensitivity of human cells/tissues relative to other species, emetic effects in primates, epidemiological association with gastroenteritis and chronic disease in humans, and surveillance in cereal crops worldwide.
Toxicology of deoxynivalenol (vomitoxin).
TLDR
Deoxynivalenol (DON), a trichothecene, is prevalent worldwide in crops used for food and feed production, including in Canada and the United States and should be treated as an important food safety issue.
Toxicology of deoxynivalenol (vomitoxin).
TLDR
Deoxynivalenol (DON), a trichothecene, is prevalent worldwide in crops used for food and feed production, including in Canada and the United States and should be treated as an important food safety issue.
Deoxynivalenol: Toxicity, mechanisms and animal health risks
Mechanisms of deoxynivalenol-induced gene expression and apoptosis
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  • Biology, Medicine
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TLDR
In vitro exposure to low trichothecene concentrations upregulates expression both transcriptionally and post-transcriptionally of cytokines, chemokines and inflammatory genes with concurrent immune stimulation, whereas exposure to high concentrations promotes leukocyte apoptosis with concomitant immune suppression.
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  • 2010
TLDR
Findings for the first time provide evidence for a mechanism of growth inhibition that links the well-established role of DON as a modulator of cytokine expression with disruption of GH signaling and show that DON suppresses growth in mice by reducing growth hormone (GH) signaling through mechanisms mediated by insulin-like growth factor 1 (IGF1) and insulin like growth factor acid-labile substance (IGFs).
Effects of trichothecene mycotoxins on eukaryotic cells: A review
The major products of the trichothecene mycotoxin biosynthetic pathway produced in a species– and sometimes isolate–specific manner by cereal–pathogenic Fusarium fungi include T–2 toxin,
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TLDR
Results showed that human BFU-E are as sensitive to trichothecenes as human CFU-GM, except for DON, in the range of concentrations tested, indicating that differentiation of erythroblastic progenitors could be perturbed by these mycotoxins.
Lipopolysaccharide and the trichothecene vomitoxin (deoxynivalenol) synergistically induce apoptosis in murine lymphoid organs.
TLDR
The results provide qualitative and quantitative evidence for the hypothesis that LPS exposure markedly amplifies the toxicity of trichothecenes and that the immune system is a primary target for these interactive effects.
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