Deoxymyoglobin is a nitrite reductase that generates nitric oxide and regulates mitochondrial respiration.

  title={Deoxymyoglobin is a nitrite reductase that generates nitric oxide and regulates mitochondrial respiration.},
  author={Sruti S. Shiva and Zhi Huang and Rozalina Grubina and Junhui Sun and Lorna A. Ringwood and Peter Macarthur and Xiuli Xu and Elizabeth Murphy and Victor M. Darley-Usmar and Mark T Gladwin},
  journal={Circulation research},
  volume={100 5},
Previous studies have revealed a novel interaction between deoxyhemoglobin and nitrite to generate nitric oxide (NO) in blood. It has been proposed that nitrite acts as an endocrine reservoir of NO and contributes to hypoxic vasodilation and signaling. Here, we characterize the nitrite reductase activity of deoxymyoglobin, which reduces nitrite approximately 36 times faster than deoxyhemoglobin because of its lower heme redox potential. We hypothesize that physiologically this reaction releases… CONTINUE READING
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Endothelial nitric oxide synthase reduces nitrite anions to NO under anoxia

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