Deoxyglucose and reduced glutathione mimic effects of hypoxia on K+ and Ca2+ conductances in pulmonary artery cells.

@article{Yuan1994DeoxyglucoseAR,
  title={Deoxyglucose and reduced glutathione mimic effects of hypoxia on K+ and Ca2+ conductances in pulmonary artery cells.},
  author={X J Yuan and Mary L Tod and Lewis J. Rubin and Mordecai P. Blaustein},
  journal={The American journal of physiology},
  year={1994},
  volume={267 1 Pt 1},
  pages={
          L52-63
        }
}
Hypoxia-induced pulmonary vasoconstriction (HPV) is triggered by a rise in cytosolic Ca2+ concentration ([Ca2+]i) that is partially controlled by voltage-gated Ca2+ channels. Hypoxia inhibits voltage-gated K+ (KV) channels in pulmonary artery (PA) myocytes. This depolarizes the cells, opens voltage-gated Ca2+ channels, thereby increases [Ca2+]i, and initiates HPV. In intact animals and isolated perfused lungs, metabolic inhibitors and reducing agents augment HPV. We compared the effects of… CONTINUE READING
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