Deoxyelephantopin impairs growth of cervical carcinoma SiHa cells and induces apoptosis by targeting multiple molecular signaling pathways

@article{Farha2014DeoxyelephantopinIG,
  title={Deoxyelephantopin impairs growth of cervical carcinoma SiHa cells and induces apoptosis by targeting multiple molecular signaling pathways},
  author={Arakkaveettil Kabeer Farha and S Dhanya and Sivasankaran Nair Mangalam and Balakrishnan Sreedevi Geetha and Panickamparambil Gopalakrishnan Latha and Prathapan Remani},
  journal={Cell Biology and Toxicology},
  year={2014},
  volume={30},
  pages={331-343}
}
Deoxyelephantopin, a sesquiterpene lactone extracted and purified from Elephantopus scaber, has been shown to exhibit antitumor and hepatoprotective activities. The purpose of this study was to investigate the antiproliferative and apoptosis-inducing properties of deoxyelephantopin in SiHa cells and to elucidate the underlying molecular mechanisms. Deoxyelephantopin inhibited growth of SiHa cells and triggered apoptosis. Apoptosis was accompanied by sequential activation of caspases (8, 9, 3… CONTINUE READING

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