Deoxycytidine kinase-mediated toxicity of deoxyadenosine analogs toward malignant human lymphoblasts in vitro and toward murine L1210 leukemia in vivo.

@article{Carson1980DeoxycytidineKT,
  title={Deoxycytidine kinase-mediated toxicity of deoxyadenosine analogs toward malignant human lymphoblasts in vitro and toward murine L1210 leukemia in vivo.},
  author={Dennis Anthony Carson and D Bruce Wasson and Jonathan Kaye and Buddy Ullman and Dwight W. Martin and Roland K. Robins and John A. Montgomery},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1980},
  volume={77 11},
  pages={6865-9}
}
An inherited deficiency of adenosine deaminase (adenosine aminohydrolase, EC 3.5.4.4) produces selective lymphopenia and immunodeficiency disease in humans. Previous experiments have suggested that lymphospecific toxicity in this condition might result from the selective accumulation of toxic deoxyadenosine nucleotides by lymphocytes with high deoxycytidine kinase, levels and low deoxynucleotide dephosphorylating activity. The present experiments were designed to determine if deoxyadenosine… CONTINUE READING

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